Find Jobs
Hire Freelancers

Academic Writing thesis

$50 USD / hour

已关闭
已发布超过 9 年前

$50 USD / hour

Deadline: Monday 8 September 2014, 19:30:00 7 Page(s) - 1925 Words APA with 15 references 25$/1000 words Total budget: 50$ Not negotiable NB: IF our client doesn't raise any issue with 4 day payments shall be sent to the selected freelancer My work is based on genetic progression from Barrett's oesophagous to Oesophageal adenocarcinoma. Have sent my 3 chapters and need help with final discussion. Background: Project 1: Barrett’s oesophagus (BO) is a common premalignant condition in which the normal squamous epithelium of the lower end of the human oesophagus is replaced by a columnar, intestinal phenotype. BO is the predominant risk factor for the development of oesophageal adenocarcinoma (OA). The incidence of BO in Western countries has increased by 30-40 fold in the last 25 years and carries a 0.12% annual risk of developing OA. Therefore, there is a clear clinical need to understand the genetic progression of Barrett’s oesophagus so that we can identify the patients who are at a higher risk of developing OA. Earlier studies into the genetic evolution of BO have lead to the theory that BO is a genetically clonal lesion from which a cancer can arise (Galipeau et al., 1999). However, recent work by Leedham et al. has shown that there are multiple independent clones present; therefore BO is a genetically heterotypic disease. Furthermore, Maley et al. have shown that genetic diversity increases the risk of cancer progression. My plan is to investigate genetic diversity in Barrett’s dysplasia and cancer and analyse which clones progress to cancer. My hypothesis is that the Barrett’s metaplasia-dysplasia-carcinoma (MDC) sequence is characterised by multiple genetically diverse clones in dysplasia but one clone progresses to cancer. Project 2: Around 50% of patients who undergo oesophagectomy for OA develop neo-Barrett’s lesions (neo-BO) over a period of 3-5 years post surgery. This could be due to a field effect, wherein pre-neoplastic cells exist at multiple sites of histologically-normal areas of epithelium. This carries an important clinical implication: apparently normal epithelium surrounding the resection may possess genetic abnormalities that predispose to neo-BO or cancer re-development: so called field cancerization. Project 3: A long-term follow-up up patients with crypt dysplasia showed the development of either synchronous or metachronous traditional dysplasia or cancer on follow-up (Lomo et al., 2006): it was subsequently proposed that dysplasia begins in the bases of the crypts in Barrett’s esophagus and progresses with time to involve the upper portions of the crypts and surface epithelium (Coco et al., 2011). However, it is not yet clear whether, any genetic changes found in the dysplastic cells at the crypt bases are shared by those cells in the upper part of the crypt. PFA the chapters 3,4 and 5
项目 ID: 6420641

关于此项目

8提案
远程项目
活跃9 年前

想赚点钱吗?

在Freelancer上竞价的好处

设定您的预算和时间范围
为您的工作获得报酬
简要概述您的提案
免费注册和竞标工作
8威客以平均价$52 USD/小时来参与此工作竞价
用户头像
A proposal has not yet been provided
$52 USD 在3天之内
4.8 (1501条评论)
9.0
9.0
用户头像
I lived in England for the better part of my life (including my education) so English is my native language. I have been an academic writer for 3 years and have written over 300 essays, reports and dissertations. I am familiar with all the citation styles. I studied Economics and Management at the prestigious University of Warwick in England. I have also cleared the CFA Program. My work will be 100% unique, well researched and structured. I have got over 100 positive reviews in less than 4 months. It goes to show my ability to deliver quality work on time.
$52 USD 在3天之内
4.8 (122条评论)
6.6
6.6
用户头像
A proposal has not yet been provided
$50 USD 在1天之内
4.7 (264条评论)
6.5
6.5
用户头像
I am a Public Health and Medical professional, Writer, Medical Writer and researcher as well. I am working as a writer since since 2011. I have good experience in research. Kindly consider me. Regards!
$55 USD 在1天之内
4.7 (3条评论)
1.4
1.4
用户头像
Hi, hope you are fine .i have seen detail and can do it .Kindly give me this job. Thank you Regards
$55 USD 在1天之内
0.0 (0条评论)
0.0
0.0
用户头像
hi, this is mandeep dhalor. i can do this thesis writing for you and reutrn it to you by 8th sept. i know medical writing and can write excellent papers for you. your work shall be done appreciably and on time. looking forward, thanx, mandeep dhalor
$55 USD 在3天之内
0.0 (0条评论)
0.0
0.0

关于客户

KENYA的国旗
NAIROBI, Kenya
5.0
6
会员自11月 5, 2013起

客户认证

谢谢!我们已通过电子邮件向您发送了索取免费积分的链接。
发送电子邮件时出现问题。请再试一次。
已注册用户 发布工作总数
Freelancer ® is a registered Trademark of Freelancer Technology Pty Limited (ACN 142 189 759)
Copyright © 2024 Freelancer Technology Pty Limited (ACN 142 189 759)
加载预览
授予地理位置权限。
您的登录会话已过期而且您已经登出,请再次登录。