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联系Filipe Ricardo Pires De C.询问您的工作详情
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$5.00 USD
U
•
经验
FELLOWSHIP IN BIOMEDICAL SCIENCES
1月 2012 - 12月 2016 (4 年, 11 个月)
PhD fellowship to elaborate my PhD thesis named “Characterization of bone pathologies in the ins2akita mouse, a new model for diabetes insulin-dependent: contribution for a better understanding of the disease in humans”. I have work with two animal models of type 1 diabetes, the mutant ins2akita mice and the the trangenic Tg(ins:nfsb-mcherry) zebrafish. During my PhD i have focused in understanding the effects of diabetes on bone metabolism
教育
training Programming for Data Science
（少于一年）
training THREE DAY PROTEOMICS COURSE: FROM 2DE TO PROTEIN IDENTIFICATION BY MASS SPECTROMETRY
（少于一年）
PhD in Biomedical Sciences
(4 年)
资质
“STRIKE HARD ON OBESITY” PROJECT
High school Pinheiro e Rosa, Faro, Portugal
2010
Develop weight loss promotion activities and monitoring of body composition among school population.
Grade: 19/20
ACADEMIC INTERNSHIP – PROFESSOR
Basic School 2/3 Dr. J.J Neves Júnior, Faro
2003
I developed the work as a teacher accumulating experience in the preparation of classes and exploration of contents directed to the proposed needs.
Grade: 17/20
出版物
Analyses of Gait and Jump Tasks in Female Obese Adolescents
Pediatric Exercise Science
In spite of the advances in knowledge on the multi-factorial nature of obesity, many questions related to the consequences of the disease continue to be unanswered. Several studies have reported biomechanic and kinematic adaptation and alterations in walking and in tasks of every day life, motivated by the additional load of fat mass in children and adults.
Understanding the potential of two novel methodologies for the treatment of type 1 diabetes mellitus
Journal of Biomedical Informatics (under review)
Epidemiologic studies reveal that the fight against diabetes is being lost, so to overcome this serious health problem every strategy should be taken seriously. In this work, based on in silico data, we discuss the therapeutic potential for type 1 Diabetes Mellitus of two novel strategies.
Improved regeneration and de novo bone formation in a diabetes zebrafish model.
Wound Repair and Regeneration
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol) and a calcimimetic (cinacalcet), in fin regeneration and de novo mineralization in a zebrafish model of diabetes.
Altered bone architecture in the type 1 diabetes mouse model ins2akita
Journal of cellular Physiology (under review)
Type 1 diabetes has been associated to several bone alterations including increased fracture risk and bone loss. To determine the effect of long term diabetes on bone we used adult and aging Ins2Akita mice that develop diabetes. We concluded that increased trabecular and decreased cortical bone volume is caused by reduced bone formation and reduced bone resorption. Reduced leptin and insulin signaling in bone cells are responsible for reduced metabolic actions of osteoblasts and osteoclasts.
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